The division of neuro-oncology is actively involved in research to advance the treatment of gliomas and other brain tumors. Clinical trials are offered to carefully selected patients and serve as an adjunct to standard of care. These innovative treatments include novel preparations of chemotherapeutic drugs designed to bypass physiological barriers. Immunotherapy, harnessing the patient’s own immune system to fight cancer is another mechanism that has been developed to treat brain cancer and involves the administration of vaccines directed to brain tumors. Treatment paradigms based on the manipulation of the brain tumor genome-gene therapy is also offered to broaden the opportunity for oncologic control.